Class LeadingStrandSynthesis

Manages continuous synthesis of the leading strand during DNA replication.

Index

Constructors

Properties

isActive organism polymerase synthesizedLength

Methods

advance getCurrentPosition getProgress getProofreadingThreshold getSpeed getState getSynthesizedLength initiateSynthesis isSynthesizing stopSynthesis

Constructors

constructor

new LeadingStrandSynthesis(organism, startPosition?): LeadingStrandSynthesis
Creates a new leading strand synthesis manager.
Parameters
- organism: OrganismProfile
  Organism profile for biological parameters
- startPosition: number = 0
  Starting position for synthesis
Returns LeadingStrandSynthesis
- Defined in src/utils/replication/LeadingStrandSynthesis.ts:28

Properties

`Private` isActive

isActive: boolean = false

`Private` `Readonly` organism

organism: OrganismProfile

Organism profile for biological parameters

`Private` `Readonly` polymerase

polymerase: DNAPolymerase

`Private` synthesizedLength

synthesizedLength: number = 0

Methods

advance

advance(basePairs): ReplicationEvent[]
Advances leading strand synthesis by the specified number of base pairs.
Parameters
- basePairs: number
  Number of base pairs to synthesize
Returns ReplicationEvent[]
Array of replication events generated during synthesis
- Defined in src/utils/replication/LeadingStrandSynthesis.ts:59

getCurrentPosition

getCurrentPosition(): number
Gets the current position of the polymerase.

Returns number
Current position
- Defined in src/utils/replication/LeadingStrandSynthesis.ts:101

getProgress

getProgress(totalLength): number
Calculates synthesis progress from start position to current position.
Parameters
- totalLength: number
  Total length of DNA being replicated
Returns number
Progress as percentage (0-100)
- Defined in src/utils/replication/LeadingStrandSynthesis.ts:136

`Private` getProofreadingThreshold

getProofreadingThreshold(): number
Gets the threshold for triggering proofreading events. Based on biological research, proofreading occurs periodically during synthesis.

Returns number
Minimum base pairs before proofreading
- Defined in src/utils/replication/LeadingStrandSynthesis.ts:149

getSpeed

getSpeed(): number
Gets the current synthesis speed for the organism.

Returns number
Speed in base pairs per second
- Defined in src/utils/replication/LeadingStrandSynthesis.ts:92

getState

getState(): {
    isActive: boolean;
    position: number;
    speed: number;
    synthesizedLength: number;
}
Creates a summary of current synthesis state.

Returns {
    isActive: boolean;
    position: number;
    speed: number;
    synthesizedLength: number;
}
Synthesis state summary
- isActive: boolean
- position: number
- speed: number
- synthesizedLength: number
- Defined in src/utils/replication/LeadingStrandSynthesis.ts:158

getSynthesizedLength

getSynthesizedLength(): number
Gets the total length of DNA synthesized.

Returns number
Total synthesized length in base pairs
- Defined in src/utils/replication/LeadingStrandSynthesis.ts:110

initiateSynthesis

initiateSynthesis(primerPosition): ValidationResult<void>
Initiates leading strand synthesis with a primer.
Parameters
- primerPosition: number
  Position where primer is located
Returns ValidationResult<void>
Validation result with success/failure
- Defined in src/utils/replication/LeadingStrandSynthesis.ts:41

isSynthesizing

isSynthesizing(): boolean
Checks if synthesis is currently active.

Returns boolean
True if synthesis is active
- Defined in src/utils/replication/LeadingStrandSynthesis.ts:119

stopSynthesis

stopSynthesis(): void
Stops leading strand synthesis.

Returns void
- Defined in src/utils/replication/LeadingStrandSynthesis.ts:126